Fluphenazine Decanoate in Chronic Schizophrenia
نویسنده
چکیده
Introduction of chlorpromazine by Delay and Danikcr in 1952 revolutionized the treatment of acute schizophrenia. However, chronic form of the illness still remains a challenge, mainly because of noncompliance of the patients with the therapeutic regimen (Diamond and Marks, 1960; Olson and Peterson, 1960; Hare and Willcox, 1967 ; Wilson and Enoch, 1967 and Ayd, 1975). Another factor is the erratic absorption of neuroleptics in these cases (Lewis et al., 1971). Long acting phenothiazines were developed to overcome these problems. Fluphenazine enanthate, probably the first such preparation, though useful in chronic schizophrenia, had a rather short (1-2 weeks) duration of action and marked extrapyramidal effects (Miller and Daniel, 1967; Shah et al., 1971 and Bagadia et al., 1972). Fluphenazine decanoate, a newer product, has been claimed to produce less extrapyramidal effects and has an action lasting for 3-4 weeks (Falton et al., 1978 and Silverstone and Turner, 1978). There are still rather few reports on its efficacy and safety-particularly from our country (Gahlot et al., 1977 and Bagadia et al., 1979). Further, these reports have been of rather short duration—lasting over 4-5 months only—thus making it difficult to assess the efficacy of the drug in an illness continuing over years with unpredictably fluctuating course. This presentation, therefore, aims at reporting the results of a long term (1 -3 years) trial of the drug in a group of chronic schizophrenics.
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